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Metabolic · Long-acting amylin analog

Cagri

10 mg · 37 residues · 4409 Da

$95.00per vial

Size$9.50/mg

10 mg Lyophilised · sealed vial

Quantity10+ of one compound: 40% off

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  • 7 tests, every lotIndependent lab
  • 2 Day ShippingFrom the USA, tracked
  • Encrypted checkoutSSL secured
  • PassedSterility & endotoxin
  • PassedIdentity & purity, 99.61%

For in-vitro research use only. Not for human or animal use.

Researchers also add

01Verified test results

Every lot, independently tested.

Cagri lot SA-CAG-2610 was tested Oct 8, 2026 at an independent laboratory before it shipped. Every value is printed against its limit, so a pass means something.

Independent labIndependent third-party laboratorySample data

Certificate of analysis

99.61%

Purity by HPLC

Profile drawn from the reported purity

Lot
SA-CAG-2610
Tested
Oct 8, 2026
Labelled
10 mg
Measured
10.10 mg
7 of 7 within limitsQR on every label
Full release panel7 passed · 0 flagged
  • PurityHPLC · limit ≥ 99.0%99.61%Pass
  • IdentityMass spectrometry · limit 4409.0 ± 1.0 Da4409.3 DaPass
  • Net contentQuantitative HPLC · limit ≥ 10 mg10.10 mgPass
  • EndotoxinLAL assay · limit ≤ 0.5 EU/mg0.11 EU/mgPass
  • SterilityMembrane filtration · limit No growthNo growthPass
  • Heavy metalsICP-MS · limit ≤ 10 ppm total1.0 ppmPass
  • MoistureKarl Fischer · limit ≤ 8.0%3.5%Pass

Purity by HPLC, identity by mass spectrometry, net content by quantitative HPLC, endotoxin by LAL, sterility by membrane filtration, heavy metals by ICP-MS and moisture by Karl Fischer. Report SA-CAG-2610-01, Oct 8, 2026. Open the lot record.

Every lot on record

Open any lot's certificate. Your order ships from the current released lot, and its QR code opens this record.

All 2 Cagri lots
Latest
Cagri 10 mgLot SA-CAG-2610

99.61%

HPLC purity

Labelled10 mgMeasured10.10 mg+1.0%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Oct 8, 2026 · 7/7 assays · sample

Cagri 10 mgLot SA-CAG-2609

99.77%

HPLC purity

Labelled10 mgMeasured10.24 mg+2.4%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Sep 10, 2026 · 7/7 assays · sample

02Verify your vial

Three steps from label to lab.

  1. 01Scan the label

    Every vial label carries a QR code. Point your phone camera at it.

  2. 02Land on its record

    The code opens that lot's certificate with every assay value. No phone? Type the lot from your packing slip on Verify a lot.

  3. 03Check it with the lab

    Each signed certificate links to the lab's own verification page, so the report can be confirmed independently of us.

03Analytical identity

Cagri, molecule by molecule.

Studied in amylin and calcitonin receptor models in vitro.

CompoundLong-acting amylin analog
FormulaC194H312N54O59S2
Molecular weight4409 Da
Residues37
FormLyophilised powder, 10 mg
StorageSealed at -20 °C, away from light and moisture

Sequence

37-residue chain. The full sequence and its mass-spec confirmation are on each lot certificate.

04In the lab

How Cagri is studied to work.

Cagri is a lipidated, long-acting amylin analog that activates amylin receptors and the calcitonin receptor through Gs. In laboratory models its energy-balance effects depend on brain amylin receptors and on Calcr/Prlh brainstem neurons.

Compound

CagriLong-acting acylated amylin analog
  1. Dual receptor binding

    Receptor-Gs complexes

    • AMY1R + CTR
    • Gs

    Endpoint studied

    Gs signaling

    Cryo-EM structures show one bypass binding mode at both receptors and non-selective Gs activation.

    Gu 2026 · PMID 40847076
  2. Brain amylin receptors

    Brainstem neurons

    • RAMP1 / RAMP3
    • AMY1R / AMY3R
    • c-Fos

    Endpoint studied

    Neuron activation

    Without RAMP1 and RAMP3 its potency fell and its area postrema c-Fos signal dropped 57%.

    Carvas 2025 · PMID 40609154
  3. Calcr/Prlh neurons

    Dorsal vagal complex

    • Calcr
    • Prlh

    Endpoint studied

    Energy-balance effects

    Longer exposure raised Prlh in Calcr/Prlh neurons; knocking down Prlh blocked its effects.

    Ludwig 2026 · PMID 42260119

Pathways as reported in the cited laboratory studies. For in-vitro research use only.

05Research history

5 years in the literature.

5 milestones, each linked to its PubMed record

  1. 2021

    The Journal of Pharmacology and Experimental Therapeutics

    Receptor pharmacology profiled

    AM833 (cagri), a lipidated amylin analog, is profiled across 25 endpoints as a nonselective amylin and calcitonin receptor agonist.

    PubMed · PMID 33727283
  2. 2021

    Journal of Medicinal Chemistry

    Design of a long-acting analog

    Structure-activity work on amylin, a hormone prone to forming fibrils, leads to cagri, a stable, lipidated long-acting analog.

    PubMed · PMID 34288673
  3. 2025

    Nature Communications

    Receptor structures solved

    Cryo-EM structures at AMY1R, AMY2R, AMY3R and CTR show an amylin-like binding mode with distinct receptor dynamics.

    PubMed · PMID 40204768
  4. 2025

    EBioMedicine

    Brain receptor dependence

    In an obesity model its effects depended on amylin receptors 1 and 3, with c-Fos activation in brainstem neurons.

    PubMed · PMID 40609154
  5. 2026

    Nature Metabolism

    A brainstem cell atlas

    An atlas of over 530,000 brainstem cells across species points to Calcr/Prlh neurons as mediators of its effects.

    PubMed · PMID 42260119 Latest

Laboratory research only, cited for research context. Not a claim about use in people.

06Questions

Frequently asked questions.

About Cagri, its certificate and your order.

Need assistance? We’re here to help.

Email [email protected], Monday to Friday. A person replies within one business day.

01Which lot will I receive?

The current released lot, SA-CAG-2610. Scan the QR code on the vial label to open its certificate. The lot number is also on your packing slip, and the full certificate is here.

02Is the certificate real, and can I check it?

Every certificate is issued by an independent laboratory. Each lot has its own public record page with every assay value, and a link to verify the report on the lab's own site once the signed PDF is posted.

03Why does net content show more than 10 mg?

Vials are filled slightly over the labelled mass so that every vial meets it. Net content is measured on each lot and published as a number, not a pass.

04What if the vial arrives without vacuum or damaged?

Email [email protected] within 7 days with your order number and a photo and we will replace it.

05When will it ship?

Orders by 2 PM ET on a weekday ship the same day, with tracking emailed when the label prints.

06Is Cagri for human use?

No. It is sold strictly for in-vitro laboratory research and is not for human or animal use of any kind.

07Complete the box

Every vial counts toward your price.

3+ vials 25% off and 5+ vials 30% off across any mix, 10+ of one compound 40% off, 50+ of one compound 50% off.

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Cagri10 mg · $95.00
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