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TB-500 10 mg research vial

Tissue + immune · Thymosin Beta-4 (Tβ4) peptide

TB-500

10 mg · 43 residues · 4963.44 Da

$85.00per vial

Size$8.50/mg

10 mg Lyophilised · sealed vial

Quantity10+ of one compound: 40% off

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  • 7 tests, every lotIndependent lab
  • 2 Day ShippingFrom the USA, tracked
  • Encrypted checkoutSSL secured
  • PassedSterility & endotoxin
  • PassedIdentity & purity, 99.41%

For in-vitro research use only. Not for human or animal use.

Researchers also add

01Verified test results

Every lot, independently tested.

TB-500 lot SA-TB5-2611 was tested Oct 14, 2026 at an independent laboratory before it shipped. Every value is printed against its limit, so a pass means something.

Independent labIndependent third-party laboratorySample data

Certificate of analysis

99.41%

Purity by HPLC

Profile drawn from the reported purity

Lot
SA-TB5-2611
Tested
Oct 14, 2026
Labelled
10 mg
Measured
10.14 mg
7 of 7 within limitsQR on every label
Full release panel7 passed · 0 flagged
  • PurityHPLC · limit ≥ 99.0%99.41%Pass
  • IdentityMass spectrometry · limit 4963.4 ± 1.0 Da4963.5 DaPass
  • Net contentQuantitative HPLC · limit ≥ 10 mg10.14 mgPass
  • EndotoxinLAL assay · limit ≤ 0.5 EU/mg0.11 EU/mgPass
  • SterilityMembrane filtration · limit No growthNo growthPass
  • Heavy metalsICP-MS · limit ≤ 10 ppm total0.8 ppmPass
  • MoistureKarl Fischer · limit ≤ 8.0%4.0%Pass

Purity by HPLC, identity by mass spectrometry, net content by quantitative HPLC, endotoxin by LAL, sterility by membrane filtration, heavy metals by ICP-MS and moisture by Karl Fischer. Report SA-TB5-2611-01, Oct 14, 2026. Open the lot record.

Every lot on record

Open any lot's certificate. Your order ships from the current released lot, and its QR code opens this record.

All 2 TB-500 lots
Latest
TB-500 10 mgLot SA-TB5-2611

99.41%

HPLC purity

Labelled10 mgMeasured10.14 mg+1.4%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Oct 14, 2026 · 7/7 assays · sample

TB-500 10 mgLot SA-TB5-2609

99.27%

HPLC purity

Labelled10 mgMeasured10.09 mg+0.9%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Sep 9, 2026 · 7/7 assays · sample

02Verify your vial

Three steps from label to lab.

  1. 01Scan the label

    Every vial label carries a QR code. Point your phone camera at it.

  2. 02Land on its record

    The code opens that lot's certificate with every assay value. No phone? Type the lot from your packing slip on Verify a lot.

  3. 03Check it with the lab

    Each signed certificate links to the lab's own verification page, so the report can be confirmed independently of us.

03Analytical identity

TB-500, molecule by molecule.

Studied in cell-migration and actin-binding models in vitro.

CompoundThymosin Beta-4 (Tβ4) peptide
FormulaC212H350N56O78S
Molecular weight4963.44 Da
Residues43
FormLyophilised powder, 10 mg
StorageSealed at -20 °C, away from light and moisture

Sequence

43-residue chain. The full sequence and its mass-spec confirmation are on each lot certificate.

C212H350N56O78S4963.44 Da
Drag to turn
Residues · hover to locate43 residues
Heavy atoms
347
Bonds
350
Composition
C212 N56 O78 S1
Rings
4
Metal centre
None
Chain length
43 residues

Every heavy atom is placed from the sequence with ideal bond lengths and angles, so the connectivity is exact. The pose is idealised (an ideal helix) and is not a measured conformation. Identity for each lot is confirmed on its certificate.

Structure viewer

04In the lab

How TB-500 is studied to work.

TB-500 is LKKTETQ, the actin-binding site of thymosin beta-4, a peptide that binds actin monomers and blocks polymerization. Signaling studies used the full peptide: ILK-Akt in heart muscle cells and PI3K-Akt-eNOS in endothelial progenitors.

Compound

TB-500Synthetic LKKTETQ, the thymosin beta-4 actin site

  1. Cell survival

    Cardiomyocytes

    • PINCH
    • ILK
    • Akt

    Endpoint studied

    Migration and survival

    Formed a complex with PINCH and ILK that activated Akt; heart muscle cells migrated and survived more.

    Bock-Marquette 2004 · PMID 15565145

  2. Endothelial migration

    Endothelial progenitors

    • PI3K
    • Akt
    • eNOS

    Endpoint studied

    Directional migration

    Akt, eNOS and ERK1/2 were phosphorylated; PI3K or eNOS inhibitors blocked migration, an ERK inhibitor did not.

    Qiu 2009 · PMID 19247195

  3. Inflammation signaling

    Corneal epithelial cells

    • TNF-alpha
    • NF-kB p65

    Endpoint studied

    Less nuclear NF-kB

    After TNF-alpha, lower nuclear NF-kB, NF-kB activity, p65 phosphorylation and p65 nuclear entry.

    Sosne 2007 · PMID 17254567

Pathways as reported in the cited laboratory studies. For in-vitro research use only.

05Research history

29 years in the literature.

5 milestones, each linked to its PubMed record

  1. 1981

    Proceedings of the National Academy of Sciences of the United States of America

    Sequence determined

    The 43-amino-acid sequence of thymosin beta 4, isolated from thymus, is determined; its N-terminus carries an acetyl group.

    PubMed · PMID 6940133
  2. 1991

    The Journal of Biological Chemistry

    An actin-sequestering peptide

    Fx, the peptide holding unpolymerized actin in platelets, proves identical to thymosin beta 4 and forms a 1:1 complex with actin monomers.

    PubMed · PMID 1999398
  3. 2003

    Wound Repair and Regeneration

    The LKKTETQ fragment

    A seven-amino-acid peptide matching the actin-binding domain, LKKTETQ, aided dermal repair in an aged wound model, like the full peptide.

    PubMed · PMID 12581423
  4. 2004

    Nature

    ILK and heart cell survival

    Thymosin beta4 forms a complex with PINCH and ILK that activates Akt, supporting heart muscle cell migration and survival.

    PubMed · PMID 15565145
  5. 2010

    FASEB Journal

    Active sites mapped

    A review maps its active sites: LKKTETQ, the central actin-binding domain, is linked to vessel growth, wound repair and cell migration.

    PubMed · PMID 20179146 Latest

Laboratory research only, cited for research context. Not a claim about use in people.

06Questions

Frequently asked questions.

About TB-500, its certificate and your order.

Need assistance? We’re here to help.

Email [email protected], Monday to Friday. A person replies within one business day.

Email supportContact page
01Which lot will I receive?

The current released lot, SA-TB5-2611. Scan the QR code on the vial label to open its certificate. The lot number is also on your packing slip, and the full certificate is here.

02Is the certificate real, and can I check it?

Every certificate is issued by an independent laboratory. Each lot has its own public record page with every assay value, and a link to verify the report on the lab's own site once the signed PDF is posted.

03Why does net content show more than 10 mg?

Vials are filled slightly over the labelled mass so that every vial meets it. Net content is measured on each lot and published as a number, not a pass.

04What if the vial arrives without vacuum or damaged?

Email [email protected] within 7 days with your order number and a photo and we will replace it.

05When will it ship?

Orders by 2 PM ET on a weekday ship the same day, with tracking emailed when the label prints.

06Is TB-500 for human use?

No. It is sold strictly for in-vitro laboratory research and is not for human or animal use of any kind.

07Complete the box

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TB-50010 mg · $85.00
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