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Melanocortin · Cyclic heptapeptide melanocortin (α-MSH) analog

Melanotan II

10 mg · 7 residues · 1024.18 Da

$45.00per vial

Size$4.50/mg

10 mg Lyophilised · sealed vial

Quantity10+ of one compound: 40% off

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  • 7 tests, every lotIndependent lab
  • 2 Day ShippingFrom the USA, tracked
  • Encrypted checkoutSSL secured
  • PassedSterility & endotoxin
  • PassedIdentity & purity, 99.90%

For in-vitro research use only. Not for human or animal use.

Researchers also add

01Verified test results

Every lot, independently tested.

Melanotan II lot SA-ME1-2610 was tested Oct 8, 2026 at an independent laboratory before it shipped. Every value is printed against its limit, so a pass means something.

Independent labIndependent third-party laboratorySample data

Certificate of analysis

99.90%

Purity by HPLC

Profile drawn from the reported purity

Lot
SA-ME1-2610
Tested
Oct 8, 2026
Labelled
10 mg
Measured
10.14 mg
7 of 7 within limitsQR on every label
Full release panel7 passed · 0 flagged
  • PurityHPLC · limit ≥ 99.0%99.90%Pass
  • IdentityMass spectrometry · limit 1024.2 ± 1.0 Da1023.9 DaPass
  • Net contentQuantitative HPLC · limit ≥ 10 mg10.14 mgPass
  • EndotoxinLAL assay · limit ≤ 0.5 EU/mg0.12 EU/mgPass
  • SterilityMembrane filtration · limit No growthNo growthPass
  • Heavy metalsICP-MS · limit ≤ 10 ppm total1.2 ppmPass
  • MoistureKarl Fischer · limit ≤ 8.0%4.1%Pass

Purity by HPLC, identity by mass spectrometry, net content by quantitative HPLC, endotoxin by LAL, sterility by membrane filtration, heavy metals by ICP-MS and moisture by Karl Fischer. Report SA-ME1-2610-01, Oct 8, 2026. Open the lot record.

Every lot on record

Open any lot's certificate. Your order ships from the current released lot, and its QR code opens this record.

All 2 Melanotan II lots
Latest
Melanotan II 10 mgLot SA-ME1-2610

99.90%

HPLC purity

Labelled10 mgMeasured10.14 mg+1.4%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Oct 8, 2026 · 7/7 assays · sample

Melanotan II 10 mgLot SA-ME1-2609

99.51%

HPLC purity

Labelled10 mgMeasured10.23 mg+2.3%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Sep 10, 2026 · 7/7 assays · sample

02Verify your vial

Three steps from label to lab.

  1. 01Scan the label

    Every vial label carries a QR code. Point your phone camera at it.

  2. 02Land on its record

    The code opens that lot's certificate with every assay value. No phone? Type the lot from your packing slip on Verify a lot.

  3. 03Check it with the lab

    Each signed certificate links to the lab's own verification page, so the report can be confirmed independently of us.

03Analytical identity

Melanotan II, molecule by molecule.

Studied in melanocortin-receptor signalling models in vitro.

CompoundCyclic heptapeptide melanocortin (α-MSH) analog
FormulaC50H69N15O9
Molecular weight1024.18 Da
Residues7
FormLyophilised powder, 10 mg
StorageSealed at -20 °C, away from light and moisture

Sequence

7-residue chain. The full sequence and its mass-spec confirmation are on each lot certificate.

04In the lab

How Melanotan II is studied to work.

MT-2 (melanotan II) is a cyclic analog of alpha-MSH that binds and activates the MC1, MC3, MC4 and MC5 receptors. Laboratory work links it to MC1R-PTEN signaling in melanoma cells, nitric oxide release, and histamine from mast cells.

Compound

Melanotan IICyclic heptapeptide analog of alpha-MSH
  1. MC1R-PTEN signaling

    Melanoma cells

    • MC1R
    • PTEN
    • AKT
    • NF-κB

    Endpoint studied

    Lower COX-2 and PGE2

    PTEN rose via MC1R; migration, invasion and colony formation fell, with less COX-2 and PGE2.

    Wu 2020 · PMID 31968661
  2. Nitric oxide release

    Cavernosal tissue

    • MC3R/MC4R
    • NO synthase
    • Nitric oxide

    Endpoint studied

    Cavernosal pressure rise

    The rise was blocked by an MC3/MC4 antagonist or by NO synthase inhibition.

    Vemulapalli 2001 · PMID 11739247
  3. Mast cell histamine

    Mast cells

    • Histamine
    • H1 receptor

    Endpoint studied

    Body temperature drop

    Required mast cells; blocking H1 receptors greatly reduced the temperature drop.

    Jain 2018 · PMID 29812984

Pathways as reported in the cited laboratory studies. For in-vitro research use only.

05Research history

28 years in the literature.

5 milestones, each linked to its PubMed record

  1. 1992

    Journal of Chromatography

    First assay for MT-II

    An HPLC method is developed to measure Melanotan-II, a cyclic heptapeptide, in plasma samples.

    PubMed · PMID 1336500
  2. 1994

    Journal of Pharmaceutical Sciences

    Chemistry profiled

    Melanotan-II, a cyclic heptapeptide analog of alpha-MSH, has its pKa values and partition coefficients measured.

    PubMed · PMID 7983590
  3. 1999

    Peptides

    Key residues mapped

    Alanine swaps tested at human MC3, MC4 and MC5 receptors show Phe and Trp are essential and Arg important for activity.

    PubMed · PMID 10447101
  4. 2010

    Journal of the American Chemical Society

    MC1R-selective versions

    All 31 backbone N-methylated MT-II variants are made; several become potent, selective agonists of human MC1R.

    PubMed · PMID 20496895
  5. 2020

    International Journal of Molecular Sciences

    MC1R-PTEN in melanoma cells

    Melanoma cells migrate and invade less, with PTEN raised through MC1R and AKT/NF-κB and COX-2 signaling reduced.

    PubMed · PMID 31968661 Latest

Laboratory research only, cited for research context. Not a claim about use in people.

06Questions

Frequently asked questions.

About Melanotan II, its certificate and your order.

Need assistance? We’re here to help.

Email [email protected], Monday to Friday. A person replies within one business day.

01Which lot will I receive?

The current released lot, SA-ME1-2610. Scan the QR code on the vial label to open its certificate. The lot number is also on your packing slip, and the full certificate is here.

02Is the certificate real, and can I check it?

Every certificate is issued by an independent laboratory. Each lot has its own public record page with every assay value, and a link to verify the report on the lab's own site once the signed PDF is posted.

03Why does net content show more than 10 mg?

Vials are filled slightly over the labelled mass so that every vial meets it. Net content is measured on each lot and published as a number, not a pass.

04What if the vial arrives without vacuum or damaged?

Email [email protected] within 7 days with your order number and a photo and we will replace it.

05When will it ship?

Orders by 2 PM ET on a weekday ship the same day, with tracking emailed when the label prints.

06Is Melanotan II for human use?

No. It is sold strictly for in-vitro laboratory research and is not for human or animal use of any kind.

07Complete the box

Every vial counts toward your price.

3+ vials 25% off and 5+ vials 30% off across any mix, 10+ of one compound 40% off, 50+ of one compound 50% off.

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Melanotan II10 mg · $45.00
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