| Test | Method | Limit | Result |
|---|---|---|---|
| Purity | HPLC | ≥ 99.0% | 99.36% |
| Identity | Mass spectrometry | 2174.6 ± 1.0 Da | 2174.4 Da |
| Net content | Quantitative HPLC | ≥ 10 mg | 10.19 mg |
| Endotoxin | LAL assay | ≤ 0.5 EU/mg | 0.11 EU/mg |
| Sterility | Membrane filtration | No growth | No growth |
| Heavy metals | ICP-MS | ≤ 10 ppm total | 1.2 ppm |
| Moisture | Karl Fischer | ≤ 8.0% | 3.3% |
Mitochondrial-derived 16-residue peptide
C101H152N28O22S2
2174.64 Da · 16 residues
Cellular · Mitochondrial-derived 16-residue peptide
10 mg to 50 mg · 16 residues · 2174.64 Da
Size$6.00/mg
Quantity10+ of one compound: 40% off
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For in-vitro research use only. Not for human or animal use.
Cellular
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AICAR 50 mgCellular
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GLP-3 RT 5 mg01Verified test results
MOTS-c lot SA-MOT-2610 was tested Oct 8, 2026 at an independent laboratory before it shipped. Every value is printed against its limit, so a pass means something.
Certificate of analysis
99.36%
Purity by HPLC
Profile drawn from the reported purity
Purity by HPLC, identity by mass spectrometry, net content by quantitative HPLC, endotoxin by LAL, sterility by membrane filtration, heavy metals by ICP-MS and moisture by Karl Fischer. Report SA-MOT-2610-01, Oct 8, 2026. Open the lot record.
Open any lot's certificate. Your order ships from the current released lot, and its QR code opens this record.
99.36%
HPLC purity
Tested Oct 8, 2026 · 7/7 assays · sample
99.74%
HPLC purity
Tested Sep 10, 2026 · 7/7 assays · sample
02Verify your vial
Every vial label carries a QR code. Point your phone camera at it.
The code opens that lot's certificate with every assay value. No phone? Type the lot from your packing slip on Verify a lot.
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03Analytical identity
Studied in mitochondrial and cellular-metabolism models in vitro.
| Compound | Mitochondrial-derived 16-residue peptide |
|---|---|
| Formula | C101H152N28O22S2 |
| Molecular weight | 2174.64 Da |
| Residues | 16 |
| Form | Lyophilised powder, 10 mg, 30 mg, 50 mg |
| Storage | Sealed at -20 °C, away from light and moisture |
Sequence
Side-chain composition
Every heavy atom is placed from the sequence with ideal bond lengths and angles, so the connectivity is exact. The pose is idealised (an extended chain) and is not a measured conformation. Identity for each lot is confirmed on its certificate.
Structure viewer04In the lab
MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene. In laboratory research it inhibits the folate cycle to activate AMPK, and under metabolic stress it moves into the nucleus to regulate stress-response genes.
Compound
MOTS-c16-amino-acid peptide from mitochondrial 12S rRNASkeletal muscle
Endpoint studied
Inhibited the folate cycle and de novo purine synthesis, leading to AMPK activation.
Lee 2015 · PMID 25738459Glucose-restricted cells
Endpoint studied
Moved into the nucleus after glucose restriction, AMPK-dependent, and interacted with NRF2 at ARE genes.
Kim 2018 · PMID 29983246Mammalian cells
Endpoint studied
Raised fusion proteins OPA1 and MFN2; blocking them or MFN2 knockdown stopped GLUT4 translocation.
Bhullar 2021 · PMID 34253808Pathways as reported in the cited laboratory studies. For in-vitro research use only.
05Research history
4 milestones, each linked to its PubMed record
Cell Metabolism
A 16-amino-acid peptide encoded in the mitochondrial 12S rRNA is reported, acting on the folate cycle and AMPK.
PubMed · PMID 25738459Biochemical and Biophysical Research Communications
Less bone loss in a bone loss model, with RANKL-induced osteoclast formation inhibited partly through AMPK.
PubMed · PMID 27237975Cell Metabolism
Under metabolic stress MOTS-c moves to the nucleus, AMPK-dependent, regulating ARE genes and interacting with NRF2.
PubMed · PMID 29983246Scientific Reports
Fusion proteins OPA1 and MFN2 are needed for MOTS-c-induced GLUT4 translocation and glucose uptake in cells.
PubMed · PMID 34253808 LatestLaboratory research only, cited for research context. Not a claim about use in people.
06Questions
About MOTS-c, its certificate and your order.
Email [email protected], Monday to Friday. A person replies within one business day.
The current released lot, SA-MOT-2610. Scan the QR code on the vial label to open its certificate. The lot number is also on your packing slip, and the full certificate is here.
Every certificate is issued by an independent laboratory. Each lot has its own public record page with every assay value, and a link to verify the report on the lab's own site once the signed PDF is posted.
Vials are filled slightly over the labelled mass so that every vial meets it. Net content is measured on each lot and published as a number, not a pass.
Email [email protected] within 7 days with your order number and a photo and we will replace it.
Orders by 2 PM ET on a weekday ship the same day, with tracking emailed when the label prints.
No. It is sold strictly for in-vitro laboratory research and is not for human or animal use of any kind.
07Complete the box
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