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Melanocortin · Cyclic heptapeptide melanocortin (MC3R / MC4R) agonist

PT-141

10 mg · 7 residues · 1025.18 Da

$45.00per vial

Size$4.50/mg

10 mg Lyophilised · sealed vial

Quantity10+ of one compound: 40% off

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  • 7 tests, every lotIndependent lab
  • 2 Day ShippingFrom the USA, tracked
  • Encrypted checkoutSSL secured
  • PassedSterility & endotoxin
  • PassedIdentity & purity, 99.28%

For in-vitro research use only. Not for human or animal use.

Researchers also add

01Verified test results

Every lot, independently tested.

PT-141 lot SA-P14-2610 was tested Oct 8, 2026 at an independent laboratory before it shipped. Every value is printed against its limit, so a pass means something.

Independent labIndependent third-party laboratorySample data

Certificate of analysis

99.28%

Purity by HPLC

Profile drawn from the reported purity

Lot
SA-P14-2610
Tested
Oct 8, 2026
Labelled
10 mg
Measured
10.23 mg
7 of 7 within limitsQR on every label
Full release panel7 passed · 0 flagged
  • PurityHPLC · limit ≥ 99.0%99.28%Pass
  • IdentityMass spectrometry · limit 1025.2 ± 1.0 Da1024.9 DaPass
  • Net contentQuantitative HPLC · limit ≥ 10 mg10.23 mgPass
  • EndotoxinLAL assay · limit ≤ 0.5 EU/mg0.12 EU/mgPass
  • SterilityMembrane filtration · limit No growthNo growthPass
  • Heavy metalsICP-MS · limit ≤ 10 ppm total0.5 ppmPass
  • MoistureKarl Fischer · limit ≤ 8.0%3.0%Pass

Purity by HPLC, identity by mass spectrometry, net content by quantitative HPLC, endotoxin by LAL, sterility by membrane filtration, heavy metals by ICP-MS and moisture by Karl Fischer. Report SA-P14-2610-01, Oct 8, 2026. Open the lot record.

Every lot on record

Open any lot's certificate. Your order ships from the current released lot, and its QR code opens this record.

All 2 PT-141 lots
Latest
PT-141 10 mgLot SA-P14-2610

99.28%

HPLC purity

Labelled10 mgMeasured10.23 mg+2.3%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Oct 8, 2026 · 7/7 assays · sample

PT-141 10 mgLot SA-P14-2609

99.68%

HPLC purity

Labelled10 mgMeasured10.24 mg+2.4%
  • IdentityConfirmed
  • EndotoxinPass
  • SterilityNo growth
  • Heavy metalsPass

Tested Sep 10, 2026 · 7/7 assays · sample

02Verify your vial

Three steps from label to lab.

  1. 01Scan the label

    Every vial label carries a QR code. Point your phone camera at it.

  2. 02Land on its record

    The code opens that lot's certificate with every assay value. No phone? Type the lot from your packing slip on Verify a lot.

  3. 03Check it with the lab

    Each signed certificate links to the lab's own verification page, so the report can be confirmed independently of us.

03Analytical identity

PT-141, molecule by molecule.

Studied in melanocortin-receptor signalling models in vitro.

CompoundCyclic heptapeptide melanocortin (MC3R / MC4R) agonist
FormulaC50H68N14O10
Molecular weight1025.18 Da
Residues7
FormLyophilised powder, 10 mg
StorageSealed at -20 °C, away from light and moisture

Sequence

  1. Ac-Nle1
  2. Asp2
  3. His3
  4. D-Phe4
  5. Arg5
  6. Trp6
  7. Lys7

Side-chain composition

  • Nonpolar114%
  • Basic (+)343%
  • Acidic (-)114%
  • Modified229%

04In the lab

How PT-141 is studied to work.

PT-141 (bremelanotide) is a cyclic alpha-MSH analog that activates several melanocortin receptor subtypes, with MC4R the most discussed. Lab work links it to dopamine release in the hypothalamus and to MC3/MC4-dependent survivin loss in glioblastoma cells.

Compound

PT-141Cyclic peptide analog of alpha-MSH
  1. Hypothalamic dopamine

    Medial preoptic neurons

    • MC4R
    • Dopamine

    Endpoint studied

    Dopamine release

    Reviewed lab work points to presynaptic MC4R on medial preoptic neurons raising dopamine release.

    Pfaus 2022 · PMID 33455598
  2. Survivin suppression

    Glioblastoma cells

    • MC3R/MC4R
    • Survivin

    Endpoint studied

    Glioblastoma cell death

    Less survivin and more cell death, both canceled by an MC3/MC4 antagonist; normal human cells were spared.

    Suzuki 2024 · PMID 39197897

Pathways as reported in the cited laboratory studies. For in-vitro research use only.

05Research history

19 years in the literature.

5 milestones, each linked to its PubMed record

  1. 2007

    The Journal of Sexual Medicine

    Brain sites mapped

    A review of lab work maps its action to the medial preoptic area of the brain.

    PubMed · PMID 17958619
  2. 2022

    CNS Spectrums

    MC4R and dopamine

    A review: PT-141 activates several melanocortin receptors; presynaptic MC4R in the medial preoptic area may raise dopamine release.

    PubMed · PMID 33455598
  3. 2024

    Anticancer Research

    Glioblastoma cell study

    Survivin falls and glioblastoma cells die, effects canceled by blocking MC3 and MC4 receptors.

    PubMed · PMID 39197897
  4. 2025

    Neuropharmacology

    Reward circuit tested

    MC3R and MC4R mRNA sit mostly in VTA dopamine neurons; PT-141 did not change their expression.

    PubMed · PMID 39793696
  5. 2026

    Analytical Methods

    Degradation profiled

    Stress testing finds eight degradation products, formed by deacetylation, peptide-bond hydrolysis, oxidation and epimerization.

    PubMed · PMID 42485063 Latest

Laboratory research only, cited for research context. Not a claim about use in people.

06Questions

Frequently asked questions.

About PT-141, its certificate and your order.

Need assistance? We’re here to help.

Email [email protected], Monday to Friday. A person replies within one business day.

01Which lot will I receive?

The current released lot, SA-P14-2610. Scan the QR code on the vial label to open its certificate. The lot number is also on your packing slip, and the full certificate is here.

02Is the certificate real, and can I check it?

Every certificate is issued by an independent laboratory. Each lot has its own public record page with every assay value, and a link to verify the report on the lab's own site once the signed PDF is posted.

03Why does net content show more than 10 mg?

Vials are filled slightly over the labelled mass so that every vial meets it. Net content is measured on each lot and published as a number, not a pass.

04What if the vial arrives without vacuum or damaged?

Email [email protected] within 7 days with your order number and a photo and we will replace it.

05When will it ship?

Orders by 2 PM ET on a weekday ship the same day, with tracking emailed when the label prints.

06Is PT-141 for human use?

No. It is sold strictly for in-vitro laboratory research and is not for human or animal use of any kind.

07Complete the box

Every vial counts toward your price.

3+ vials 25% off and 5+ vials 30% off across any mix, 10+ of one compound 40% off, 50+ of one compound 50% off.

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PT-14110 mg · $45.00
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